concomitant vs concurrent chemotherapy

A total of 70 Gy was delivered over 6 weeks. Finally, accelerated radiotherapy has been shown to lead to improved locoregional control and survival in one randomized study. The main end point is the event free survival. 7 Integration of a third chemotherapy agent to the induction and concurrent chemoradiotherapy regimen may improve distant and local disease control, respectively. If a drug abuser ingests or misuses two or more drugs, either at the same time or almost at the same time, this is also called "concomitant drugs". The main acute toxicity of concurrent chemoradiotherapy was esophagitis; grade 3 esophagitis was documented in 23.5% of the patients. Submitting a report will send us an email through our customer support system. e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. Google Scholar Enjoy affordable access to Seven hundred sixteen patients were included in this trial. Reset filters. Search Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). However, no direct evidence so far demonstrated better efficacy of sequential use of chemotherapy and endocrine therapy over concurrent. Medical Oncology Concurrent chemoradiotherapy (C-CRT) with cisplatin based chemotherapy is the current standard of treatment (4-6). 26,34–36 Identification of new cytotoxic or targeted agents that can be combined concomitantly to radiotherapy … Concurrent chemotherapy in 1980s Studies Stages Arms Results Hreschyshyn et al (1979)1 GOG 04 IIIB-IVA RT alone vs RT + HU Superiority in DFS and OS rates in RT+ HU arm. Sequential vs. concurrent chemoradiation for stage III non-small cell lung cancer: randomized phase III trial RTOG 9410 Twenty-four patients were enrolled in the study. Neither PFS, cancer-free survival nor OS was statistically significantly improved in the chemotherapy arm at the time of reporting (median follow-up not stated), although there is a trend in favour of the chemotherapy [five year PFS 61% with RT vs. 74% with CT-RT: p = 0.10, five year OS 73% with RT versus 78% with CT-RT, p = 0.41]. Read and print from thousands of top scholarly journals. Materials and Methods: Forty-eight patients were treated with combined chemoradiotherapy between the years of 1990 and 1995. shielding and concomitant high-dose rate intracavitary brachytherapy with 192-iridium remote after loading system for 6 Gy to point A of the Manchester method). Purpose: For patients with advanced head and neck cancer, various combined chemoradiotherapy regimens have been used to improve local control. Do not surround your terms in double-quotes ("") in this field. The concurrent chemotherapy regimen was cisplatin (40 mg/m2/week). The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . Purpose: The aim of this study was to compare toxicity/efficacy of conventional radiotherapy using delayed accelerated concomitant boost radiotherapy (CBRT) vs. intensity-modulated radiotherapy (IMRT) in the setting of concurrent chemotherapy (CT) for locally advanced oropharyngeal carcinoma. Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. e12040 Background: Chemotherapy followed by endocrine therapy is the standard adjuvant treatment strategy for estrogen receptor-positive breast cancer patients. Bourhis J, Sire C, Graff P, et al. Patients with newly diagnosed inoperable non-small cell lung cancer received paclitaxel (100 mg/m2) as a 1-h infusion on d 1,8,15,28,35, and 42. Carboplatin plus 5-fluorouracil (carbo-5FU) is another accepted treatment option with a different toxicity profile. Read "Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer, Medical Oncology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Read "Induction and concurrent chemotherapy with concomitant boost radiotherapy in non-small cell lung cancer, Medical Oncology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Copyright © 2000 by W.B. DeepDyve's default query mode: search by keyword or DOI. https://doi.org/10.1053/ajot.2000.0210306. Biochemistry, Genetics and Molecular Biology. Median survival in the chemo-radiotherapy arm was 11.4 months vs 14 in the induction arm (P=0.154), with one-year survival of 48% and 54%, respectively. They were placed on your computer when you launched this website. The concurrent chemotherapy consisted Conclusions: Long-term results of this schedule are encouraging However. Despite the use of C-CRT with cisplatin, many patients continue to fail in the pelvis (20–25%) and at distant sites (10–20%) ( 7 - 10 ), even the Cochrane meta-analysis ( 11 ) has shown decreasing advantage of C-CRT over radiotherapy (RT) alone as the stage increases. 1 Primary sites include the parotid, submandibular, and sublingual glands. All patients with Ewing sarcoma or rhabdomyosarcoma received additional concurrent chemotherapy, including vincristine (n = 15 patients), etoposide (n = 9 patients), cyclophosphamide (n = 1 patient), and/or dactinomycin (n = 1 patient). PURPOSE: Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one. The optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. Whether concomitant drug abuse leads to an increased number of deaths was … 1995 Kragujevac - Jeremic I PMID 7844608-- "Randomized trial of hyperfractionated radiation therapy with or without concurrent chemotherapy for stage III non-small-cell lung cancer." This study was carried out to assess the outcome of concomitant chemotherapy with a “concomitant boost” radiotherapy in the treatment of advanced unresectable head and neck cancer patients. Adjuvant therapy, also known as adjunct therapy, and adjuvant care, is therapy that is given in addition to the primary or initial therapy to maximize its effectiveness. concurrent ifosfamide was 10.2 g/m2. Komaki R, Seiferheld W, Curran W, et al. Check all that apply - Please note that only the first page is available if you have not selected a reading option after clicking "Read Article". In 1996, a multicenter randomized study comparing after breast-conservative surgery, sequential vs concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) was initiated (ARCOSEIN study). These include induction chemotherapy, concomitant chemoradiotherapy, ... (CALGB) study 9431 combined induction chemotherapy and concurrent chemoradiotherapy, in the hope that patients with NSCLC may be better served by receiving both approaches to treatment rather than … The CALGB group compared induction chemotherapy with two carboplatin and taxol cycles, followed by concomitant chemo-radiotherapy, vs concomitant chemo-radiotherapy alone . To subscribe to email alerts, please log in first, or sign up for a DeepDyve account if you don’t already have one. Chemotherapy: All the patients were to receive concomitant cisplatin in dose of 30 mg/m 2 i.v. By continuing you agree to the use of cookies. Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly. Adjective (-) Existing or created in the same period of time. We'll do our best to fix them. Phase II trial, Chemo-radiotherapy for stage III unresectable non-small cell lung cancer—long-term results of a prospective study, Induction chemoterapy for non small cell carcinoma of the lung: limitations and lessons. Introduction Carcinomas of the major salivary glands constitute a heterogeneous group of rare malignant neoplasms, accounting for less than 5% of newly diagnosed head and neck cancers. 7–10 Although the response rate to induction chemotherapy is approximately 30 to 40%, long-term survival remains unchanged. 169 pts. Median survival in complete responders has not been reached. [Abstract] Int J Radiat Oncol Biol Phys 48 (3 suppl): A-5, 113, 2000. Patients who received concurrent chemotherapy were of younger age (mean age 60.5 years vs 62.9 years; P < 0.001), were less likely to be treated at an academic center (35.6% vs 41.7%; P = 0.01), more likely to be treated at a low facility volume center (83.7% vs 79.5%; P = 0.03), and more likely to have private insurance (57.5% vs 45.9%; P < 0.001). This is a randomized, multicenter, phase III trial comparing induction chemotherapy with Docetaxel, Cisplatin and 5-Fluorouracil (TPF) followed by concurrent chemoradiotherapy (Arm A) to concurrent chemoradiotherapy alone (Arm B), in nasopharyngeal cancers staged as T2b, T3, T4 and/or with lymph node involvement (≥ N1. The multivariate analysis showed that complete response to treatment was the only significant factor for OS. Concurrent chemotherapy and radiation provide for the systemic treatment of patients with micrometastatic and macrometastatic disease and simultaneously enhance local therapy in the form of chemosensitized external beam radiotherapy (EBRT). Treatment-related toxicity was acceptable with 50% of patients developing acute confluent mucositis. Concomitant chemotherapy was Des chimiothkapies ayant donni destaux de rkponse composed of cisplatin (20 mg/m2) and 5-fluorouracil tlevCs et le cisplatine ktant d&it comme un radiopo- (500 mg/m2) that were administered each Monday and tentialisateur, nousavons rka1i.k une ttude de phaseII Thursday during radiotherapy. In addition, concomitant chemoradiotherapy has been shown to be superior to induction chemotherapy in direct comparison. Leibel S et al (1987)2 RTOG group IIIB-IVA RT alone vs RT+ Misonidazole Median survival in control arm 1.9 yrs. We reviewed data of locoregionally advanced NPC patients who underwent 2 different treatment plans, 1 with induction chemotherapy followed by concurrent chemoradiotherapy (IC + … Saunders Company). However, around one-third of the patients cannot complete cisplatin because of toxicity. Copy and paste the desired citation format or use the link below to download a file formatted for EndNote. Historic cancer treatment protocols often required patients to undergo chemotherapy and radiation separately. Table 1. Conventional vs concomitant boost radiotherapy with concurrent cisplatin in advanced head and neck cancer Sushil Dashrath Meshram, Krishna M Kamble, Ashok K Diwan, Vijay K Mohobia Department of Radiation Therapy and Oncology, Government Medical College and Hospital, Nagpur, Maharashtra, India . ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Concurrent chemotherapy and “concomitant boost” radiotherapy for unresectable head and neck cancer. Two randomized trials focusing on small-eel I lung cancer have recently shown significant benefit due to … The optimal integration of chemotherapy with radiotherapy (either conventional or altered fractionation) in the management of advanced unresectable head and neck cancers is still unclear. The median and 1-yr progression-free survival rates were 9.0 mo and 27.8%, respectively. Concurrent chemotherapy is medication provided alongside radiation therapy for cancer patients. Median overall survival was 38.8 months. The optimal sequencing of chemotherapy and radiotherapy after breast surgery was largely studied but remains controversial. Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial. This patient with concomitant rectal cancer refused further chest radiation after 20 Gy of a planned 60 Gy. (10) In the present work, we measured the inactivation of methionine synthase and the concurrent homocysteine export rate of two murine and four human cell lines during nitrous oxide exposure. Phase III study of concurrent chemotherapy and radiotherapy (CT/RT) vs CT/RT followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NSCLC): outcomes update of North American Intergroup 0139 (RTOG 9309) (Abstract) Proc Am Soc Clin Oncol. Eur Arch Otorhinolarygol 1992; 249:211–215. Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place. A “concomitant boost” external beam radiotherapy approach was used with twice-daily treatment delivered during the last 2 weeks. 16. Bookmark this article. Median follow-up was 23.5 months (2-79 months). 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